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The DUEXIS® Savings Plus Program*

You may be eligible to pay as little as $20 for your DUEXIS prescription

Ask your doctor about the DUEXIS Savings Plus Program. When you present your DUEXIS prescription and your savings card to your pharmacist, you may be eligible for a discount on your pharmacy co-pay.

In many cases, your prescription for DUEXIS will be less than the cost of a month’s supply of the nonprescription drugs you would need to take to try to match the convenient dosing of just 3 DUEXIS tablets each day.

*Restrictions apply. The DUEXIS Savings Plus Program is not valid for prescriptions that are eligible to be reimbursed, in whole or in part, by Medicaid, Medicare or other federal or state health care programs, including any state prescription drug assistance programs and the Government Health Insurance Plan available in Puerto Rico (formerly known as "La Reforma De Salud"). Patients must be 18 or older. Patients will pay a minimum of $20 per fill and will receive a maximum savings of up to $130 per 30-day-supply prescription. The offer is good for a maximum of 28 fills per year or $1690 annually. Horizon Pharma reserves the right to rescind, revoke or amend this offer without notice.
To see full Terms and Conditions click here.


The following details are from the DUEXIS Prescribing Information. For more information, please see the Medication Guide and the full Prescribing Information for DUEXIS. Always talk with your health care provider if you have questions.


Important Safety Information About DUEXIS

  • Nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, a component of DUEXIS, may increase the chance of a heart attack or stroke, which can be fatal. This chance increases with longer use and in people who have heart disease or risk factors for heart disease
  • DUEXIS should not be used before or after a type of heart surgery called coronary artery bypass graft (CABG)
  • NSAID-containing medications like DUEXIS may increase the chance of stomach and intestinal problems, such as bleeding or an ulcer. These problems can happen without warning and can lead to death. Older patients may have a greater chance of developing these problems

DUEXIS is not right for everyone. People who have had asthma, hives, or an allergic reaction to aspirin or other NSAIDs should not take DUEXIS. Women in the late stages of pregnancy should not take DUEXIS. People who have had allergic reactions to medications like famotidine (histamine H2-receptor antagonists) should not take DUEXIS.

Tell your health care provider right away if you have signs of active bleeding (persistent and unexplained) while you are taking DUEXIS.

NSAID-containing medications like DUEXIS can cause high blood pressure or make existing high blood pressure worse, either of which can increase the chance of a heart attack or stroke. Your health care provider should check your blood pressure while you are taking DUEXIS.

Before you start taking DUEXIS, tell your health care provider if you have heart problems, kidney problems, or liver problems, or if you are taking medications for high blood pressure. DUEXIS can increase the chance of potentially significant liver injury and/or kidney injury, which may be fatal. Stop taking DUEXIS immediately and contact your doctor if you experience any signs and/or symptoms of liver or kidney injury.

Serious allergic reactions, including skin reactions, can happen without warning and can be life threatening. Stop taking DUEXIS and consult your health care provider immediately if you get a skin rash or if you start to have problems breathing or swallowing, or if you develop swelling of your face or throat.

The most common side effects of DUEXIS include nausea, diarrhea, constipation, upper abdominal pain, and headache.

Please see Medication Guide and full Prescribing Information on this Web site.

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Approved Uses for DUEXIS

DUEXIS, a combination of the NSAID ibuprofen and the histamine H2-receptor antagonist famotidine, is indicated for the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis and to decrease the risk of developing upper gastrointestinal ulcers, which in the clinical trials was defined as a gastric and/or duodenal ulcer, in patients who are taking ibuprofen for those indications. The clinical trials primarily enrolled patients less than 65 years of age without a prior history of gastrointestinal ulcer. Controlled trials do not extend beyond 6 months.

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