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Some Commonly Used Treatment Options to Relieve the Pain and Inflammation of Osteoarthritis and Rheumatoid Arthritis

There are many treatment options for both osteoarthritis and rheumatoid arthritis.

A few of the most commonly used oral medicines are:

  • Acetaminophen (eg, Tylenol®)
  • Opioids (also called narcotics)
  • Nonsteroidal anti-inflammatory drugs, which are also called NSAIDs (pronounced EN-SEDS)

Ibuprofen, a component of DUEXIS® (ibuprofen and famotidine) is the #1-prescribed NSAID.*

*Data not specific to the use of NSAIDs for the treatment of osteoarthritis and rheumatoid arthritis.


Prescription-strength NSAIDs have proven to be very effective for many people in relieving the symptoms of osteoarthritis and rheumatoid arthritis. Taking NSAIDs regularly, in the dose recommended to you, helps increase the likelihood that the medicine will work for you.

However, it is important to know that NSAIDs can cause a number of side effects, including effects in the upper digestive system, in some people who take them. The upper digestive system includes the stomach and the duodenum (the first part of the small intestine).

Side effects from NSAIDs can include ulcers that can occur in the protective lining of the stomach or in the duodenum. Upper digestive problems do not always occur as a result of NSAID treatment, but there are certain people who are more likely to get them.

Are you at risk of developing upper digestive ulcers? Click here to learn more.

Underlined terms are defined in the glossary.