EXPERIENCE THE 2-IN-1 BENEFITS OF DUEXIS

DUEXIS offers the powerful symptom relief you expect from your prescription- strength medicine (2400 mg ibuprofen/day)

Nonsteroidal anti-inflammatory drugs (NSAIDs), like ibuprofen, are the most commonly used drugs to ease the inflammation, pain, and stiffness that come with osteoarthritis (OA) and rheumatoid arthritis (RA). You may be familiar with ibuprofen as a trusted and effective pain reliever. But ibuprofen comes in different forms and strengths.

  • Over-the-counter (OTC) ibuprofen is available at lower doses than prescription ibuprofen (the OTC daily dosage limit is 1200 mg)
  • Prescription-strength ibuprofen can relieve BOTH arthritis pain and inflammation—dose strengths available OTC only help with pain

In a study of patients with OA, ibuprofen (800 mg 3 times daily) was shown to help patients feel less joint pain*

*This study did not include DUEXIS. The 6-week study of 809 adults with OA of the knee or hip assessed patient response to therapy, disease status, and pain walking on a flat surface (primary study endpoints).

Infographic of a human walking stating that “when walking on a flat surface, patients experienced a 77.3% greater reduction in their OA pain vs placebo.” Infographic of a human walking stating that “when walking on a flat surface, patients experienced a 77.3% greater reduction in their OA pain vs placebo.”

*This study did not include DUEXIS. The 6-week study of 809 adults with OA of the knee or hip assessed patient response to therapy, disease status, and pain walking on a flat surface (primary study endpoints).


*This study did not include DUEXIS. The 6-week study of 809 adults with OA of the knee or hip assessed patient response to therapy, disease status, and pain walking on a flat surface (primary study endpoints).

Infographic depicting a person that will not have to worry about opioid-related side effects. Infographic depicting a person that will not have to worry about opioid-related side effects.

DUEXIS can provide OA and RA symptom relief, including pain and inflammation, when treatment with a medication is preferred over surgery

DUEXIS offers relief without putting you at risk for dependence and addiction, unlike opioids

DUEXIS is the only prescription-strength ibuprofen with the built-in
stomach protection of famotidine—giving you powerful relief with about half
the risk of getting stomach ulcers vs ibuprofen alone.

Icon of the stomach organ Icon of the stomach organ

In 2 studies, DUEXIS
was shown to reduce the risk
of getting stomach uclers by
about 50% vs ibuprofen alone

DUEXIS was studied mostly in patients who were less than 65 years old and did not have a history of stomach ulcers. These patients required NSAID treatment for chronic conditions such as OA and RA. In these studies, patients taking DUEXIS had a lower risk of developing stomach ulcers than those taking ibuprofen alone during the 6-month study period.

Important things to remember when taking DUEXIS

  • DUEXIS can cause an increased risk of a heart attack or stroke that can lead to death. This risk may occur early in treatment and may increase with longer use and with increasing doses of medicine containing NSAIDs
  • DUEXIS can cause an increased risk of bleeding, ulcers, and tears (perforation) of the esophagus, stomach, and intestines. These events can occur at any time during use, without warning symptoms, and may cause death. Elderly patients and patients with a history of ulcer disease or stomach or intestine bleeding are at greater risk for getting an ulcer or bleeding
  • You should take DUEXIS exactly as prescribed, at the lowest dose possible, and for the shortest time needed

These are not all of the possible side effects of DUEXIS. Please talk with your doctor if you experience any symptoms that bother you or that do not go away. You should take DUEXIS exactly as prescribed, at the lowest dose possible and for the shortest time needed.

Learn more about how to take DUEXIS

Taking DUEXIS

INDICATIONS AND USAGE

What is DUEXIS® (ibuprofen and famotidine)?

DUEXIS contains two medicines: ibuprofen, a nonsteroidal anti‐inflammatory drug (NSAID), and famotidine, a histamine H2–receptor blocker medicine.

DUEXIS is a prescription medicine used to:

  • relieve the signs and symptoms of rheumatoid arthritis and osteoarthritis.
  • decrease the risk of developing ulcers of the stomach and upper intestines (upper gastrointestinal ulcers) in people taking ibuprofen for rheumatoid arthritis and osteoarthritis.

It is not known if DUEXIS is safe and effective in children.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about DUEXIS?

  • DUEXIS can cause an increased risk of a heart attack or stroke that can lead to death. This risk may occur early in treatment and may increase with longer use and with increasing doses of medicine containing NSAIDs.
  • DUEXIS can cause an increased risk of bleeding, ulcers, and tears (perforation) of the esophagus, stomach and intestines. These events can occur at any time during use, without warning symptoms and may cause death. Elderly patients and patients with a history of ulcer disease or stomach or intestine bleeding are at greater risk for getting an ulcer or bleeding.
  • You should take DUEXIS exactly as prescribed, at the lowest dose possible and for the shortest time needed.

DUEXIS can cause serious side effects. Stop taking DUEXIS and call your doctor or go to your emergency department right away if you get:

  • Difficulty breathing, swelling of the face or throat. These could be signs of a serious allergic reaction.
  • Chest pain, shortness of breath, weakness in one part or side of your body, or slurring of speech. These could be signs of a serious blood clotting event.
  • Upper stomach pain, upset stomach, black, tarry stools, or vomiting of blood. These could be signs of an esophagus, stomach, or intestinal ulcer, bleed, or tear. Note: if you are also taking low‐dose aspirin, you are at increased risk for esophagus, stomach, or intestinal bleeding.
  • Nausea, more tired or weaker than usual, itching, yellowing of the skin or eyes, right upper abdomen tenderness, and “flu‐like” symptoms. These could be signs of a liver problem.
  • Shortness of breath, unexplained weight gain, or swelling of the arms, legs, hands or feet. These could be signs of a serious heart problem.
  • Any type of rash. This could be a sign of a serious skin reaction.

These are not all of the possible side effects of DUEXIS. Please talk to your doctor if you experience any symptoms that bother you or that do not go away. If you take too much DUEXIS, call your poison control center at 1-800-222-1222.

Who should not use DUEXIS?

Do not take DUEXIS:

  • if you are allergic to ibuprofen, famotidine, any other histamine H2–receptor blocker, or any of the ingredients in DUEXIS. See the Medication Guide for a complete list of ingredients.
  • if you have had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAIDs.
  • right before or after heart bypass surgery called coronary artery bypass graft.

How should I take DUEXIS?

Take DUEXIS exactly as your health care provider tells you to take it. Do not change your dose or stop DUEXIS without first talking to your health care provider. Swallow DUEXIS tablets whole with liquid. Do not split, chew, crush, or dissolve the DUEXIS tablet. If you forget to take a dose of DUEXIS, take it as soon as you remember. If it is almost time for your next dose, do not take the missed dose. Take the next dose on time. Do not take 2 doses at one time to make up for a missed dose. You should not take an ibuprofen tablet and famotidine tablet together instead of taking a DUEXIS tablet, because they will not work in the same way.

What are the possible side effects of DUEXIS?

The most common side effects of DUEXIS include nausea, diarrhea, constipation, upper abdominal pain, and headache.

What other medications might interact with DUEXIS?

Do not use DUEXIS while taking other NSAIDs unless your health care provider says it is OK. NSAIDs may be present in over‐the‐counter medications for treatment of colds, fever, or insomnia; refer to the label of over‐the‐counter medications you are taking or ask your pharmacist. Do not use DUEXIS and low‐dose aspirin until you talk to your health care provider. Tell your health care provider about all of the medicines you take as some medicines can react with NSAIDs and cause serious side effects.

What should I tell my health care provider?

Before starting DUEXIS, tell your health care provider if you have a history of ulcer disease or esophagus, stomach, or intestine bleeding, liver or kidney problems, high blood pressure, heart problems, bleeding problems, asthma, or are pregnant, trying to become pregnant, or breast feeding. Also tell your health care provider about all of the medicines you take, including prescription or over‐the‐counter medicines, vitamins, or herbal supplements. Do not start taking new medicines without talking to your health care provider first.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

The risk information provided here is not comprehensive. To learn more, talk about DUEXIS with your health care provider or pharmacist. The FDA‐approved product labeling can be found at www.DUEXIS.com or 1-866-479-6742.

INDICATIONS AND USAGE

What is DUEXIS® (ibuprofen and famotidine)?

DUEXIS contains two medicines: ibuprofen, a nonsteroidal anti‐inflammatory drug (NSAID), and famotidine, a histamine H2–receptor blocker medicine.

DUEXIS is a prescription medicine used to:

  • relieve the signs and symptoms of rheumatoid arthritis and osteoarthritis.
  • decrease the risk of developing ulcers of the stomach and upper intestines (upper gastrointestinal ulcers) in people taking ibuprofen for rheumatoid arthritis and osteoarthritis.

It is not known if DUEXIS is safe and effective in children.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about DUEXIS?

  • DUEXIS can cause an increased risk of a heart attack or stroke that can lead to death. This risk may occur early in treatment and may increase with longer use and with increasing doses of medicine containing NSAIDs.
  • DUEXIS can cause an increased risk of bleeding, ulcers, and tears (perforation) of the esophagus, stomach and intestines. These events can occur at any time during use, without warning symptoms and may cause death. Elderly patients and patients with a history of ulcer disease or stomach or intestine bleeding are at greater risk for getting an ulcer or bleeding.
  • You should take DUEXIS exactly as prescribed, at the lowest dose possible and for the shortest time needed.

DUEXIS can cause serious side effects. Stop taking DUEXIS and call your doctor or go to your emergency department right away if you get:

  • Difficulty breathing, swelling of the face or throat. These could be signs of a serious allergic reaction.
  • Chest pain, shortness of breath, weakness in one part or side of your body, or slurring of speech. These could be signs of a serious blood clotting event.
  • Upper stomach pain, upset stomach, black, tarry stools, or vomiting of blood. These could be signs of an esophagus, stomach, or intestinal ulcer, bleed, or tear. Note: if you are also taking low‐dose aspirin, you are at increased risk for esophagus, stomach, or intestinal bleeding.
  • Nausea, more tired or weaker than usual, itching, yellowing of the skin or eyes, right upper abdomen tenderness, and “flu‐like” symptoms. These could be signs of a liver problem.
  • Shortness of breath, unexplained weight gain, or swelling of the arms, legs, hands or feet. These could be signs of a serious heart problem.
  • Any type of rash. This could be a sign of a serious skin reaction.

These are not all of the possible side effects of DUEXIS. Please talk to your doctor if you experience any symptoms that bother you or that do not go away. If you take too much DUEXIS, call your poison control center at 1-800-222-1222.

Who should not use DUEXIS?

Do not take DUEXIS:

  • if you are allergic to ibuprofen, famotidine, any other histamine H2–receptor blocker, or any of the ingredients in DUEXIS. See the Medication Guide for a complete list of ingredients.
  • if you have had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAIDs.
  • right before or after heart bypass surgery called coronary artery bypass graft.

How should I take DUEXIS?

Take DUEXIS exactly as your health care provider tells you to take it. Do not change your dose or stop DUEXIS without first talking to your health care provider. Swallow DUEXIS tablets whole with liquid. Do not split, chew, crush, or dissolve the DUEXIS tablet. If you forget to take a dose of DUEXIS, take it as soon as you remember. If it is almost time for your next dose, do not take the missed dose. Take the next dose on time. Do not take 2 doses at one time to make up for a missed dose. You should not take an ibuprofen tablet and famotidine tablet together instead of taking a DUEXIS tablet, because they will not work in the same way.

What are the possible side effects of DUEXIS?

The most common side effects of DUEXIS include nausea, diarrhea, constipation, upper abdominal pain, and headache.

What other medications might interact with DUEXIS?

Do not use DUEXIS while taking other NSAIDs unless your health care provider says it is OK. NSAIDs may be present in over‐the‐counter medications for treatment of colds, fever, or insomnia; refer to the label of over‐the‐counter medications you are taking or ask your pharmacist. Do not use DUEXIS and low‐dose aspirin until you talk to your health care provider. Tell your health care provider about all of the medicines you take as some medicines can react with NSAIDs and cause serious side effects.

What should I tell my health care provider?

Before starting DUEXIS, tell your health care provider if you have a history of ulcer disease or esophagus, stomach, or intestine bleeding, liver or kidney problems, high blood pressure, heart problems, bleeding problems, asthma, or are pregnant, trying to become pregnant, or breast feeding. Also tell your health care provider about all of the medicines you take, including prescription or over‐the‐counter medicines, vitamins, or herbal supplements. Do not start taking new medicines without talking to your health care provider first.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

The risk information provided here is not comprehensive. To learn more, talk about DUEXIS with your health care provider or pharmacist. The FDA‐approved product labeling can be found at www.DUEXIS.com or 1-866-479-6742.