View Important Safety Information

DUEXIS is indicated for patients suffering from the signs and symptoms of osteoarthritis and rheumatoid arthritis

Reduce the hurt of osteoarthritis and reduce the risk of developing stomach ulcers associated with ibuprofen use

Prescription-
Strength
Ibuprofen

With Built-In
Gastroprotection

In clinical trials, DUEXIS was shown to reduce the risk of developing stomach ulcers associated with ibuprofen use by about 50%

INDICATION AND USAGE

What is DUEXIS® (ibuprofen and famotidine)?

DUEXIS contains two medicines: ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), and famotidine, a histamine H2-receptor antagonist. DUEXIS is used to relieve the signs and symptoms of rheumatoid arthritis and osteoarthritis and to decrease the risk of developing ulcers in the stomach and upper intestines (upper gastrointestinal ulcers) in people who are taking ibuprofen for rheumatoid arthritis and osteoarthritis. DUEXIS was mostly studied in people less than 65 years of age and who did not have any history of ulcers of the stomach and upper intestines.

  • NSAIDs cause an increased risk of serious blood clotting events, including heart attack and stroke, which can kill you. This risk may occur early in treatment and may increase with longer use. To minimize the potential for increased risk of serious heart events while being treated with an NSAID, use the lowest effective dose for the shortest duration possible.
  • NSAIDs cause an increased risk of serious esophagus, stomach, and intestine events including bleeding, ulcers, and tears, which can kill you. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a history of ulcer disease or stomach or intestine bleeding are at greater risk for serious esophagus, stomach, and intestine events.
  • The most common side effects of DUEXIS include nausea, diarrhea, constipation, upper abdominal pain, and headache.