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Frequently Asked Questions

What should I use DUEXIS for?

DUEXIS is used to:

  • Relieve the signs and symptoms of osteoarthritis and rheumatoid arthritis
  • Decrease the risk of developing ulcers in the stomach and upper intestines (upper gastrointestinal ulcers) in patients who are taking ibuprofen for osteoarthritis or rheumatoid arthritis. DUEXIS was studied mostly in people younger than 65 years and in people who did not have a prior history of ulcers of the stomach and upper intestines

DUEXIS is a prescription 2-in-1 combination tablet that contains 2 medicines, ibuprofen and famotidine.

  1. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID)
  2. Famotidine is a histamine 2 (H2)-receptor antagonist, a medicine that may help reduce stomach acid

What is the most important information I should know about DUEXIS?

DUEXIS contains ibuprofen (an NSAID) and famotidine. NSAID-containing medicines, such as DUEXIS, increase the chance of a heart attack or stroke that can lead to death. This risk may occur early in treatment. This chance increases:

  • With increasing doses and with longer use of NSAID medicines
  • In people who have heart disease

NSAID-containing medicines, such as DUEXIS, should never be used right before or after a heart surgery called a coronary artery bypass graft (CABG).

NSAID-containing medicines, such as DUEXIS, can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Ulcers and bleeding:

  • Can happen without warning symptoms
  • May cause death

The chance of a person getting an ulcer or bleeding with NSAIDs increases with:

  • Past history of stomach ulcers, or stomach or intestinal bleeding with use of NSAIDs
  • Taking medicines called steroid hormones (corticosteroids) and blood thinners (anticoagulants, including aspirin)
  • Longer use of the NSAID
  • Increasing doses of NSAIDs
  • Smoking
  • Drinking alcohol
  • Older age
  • Advanced liver disease
  • Bleeding problems
  • Having poor health

NSAID-containing medicines, such as DUEXIS, should only be used:

  • Exactly as prescribed
  • At the lowest dose possible for your treatment
  • For the shortest time needed

How can I get DUEXIS?

DUEXIS is available by prescription only. Ask your health care provider if DUEXIS may be right for you.

Who should not take DUEXIS?

You should not take DUEXIS:

  • If you had an asthma attack, hives or other allergic reaction after taking aspirin or other NSAID medicines
  • For pain right before or after a heart surgery called coronary artery bypass graft surgery
  • If you are in the late stages of pregnancy (after 29 weeks of pregnancy)
  • If you know you are allergic to ibuprofen or famotidine or any ingredients of the drug product or to other H2-receptor antagonists

What should I tell my health care provider before starting DUEXIS?

Before you take DUEXIS, you should tell your health care provider if you:

  • Have asthma
  • Have high blood pressure (hypertension)
  • Have heart problems
  • Have a history of stomach ulcers
  • Have or had bleeding problems
  • Take or plan to take low-dose aspirin
  • Have liver or kidney problems
  • Have ulcerative colitis or Crohn's disease (inflammatory bowel disease or IBD)
  • Have any other medical conditions
  • Are pregnant or plan to become pregnant. DUEXIS should not be used by pregnant women late in their pregnancy. See Medication Guide
  • Are breastfeeding or plan to breastfeed. DUEXIS can pass into your milk and may harm your baby. You should not breastfeed while taking DUEXIS. Talk to your health care provider about the best way to feed your baby if you take DUEXIS

Can I take DUEXIS if I am taking other medicines?

You should tell your health care provider about all the medicines you take, including prescription and nonprescription medicines, vitamins and herbal supplements. Since DUEXIS contains ibuprofen, talk to your health care provider before taking any other NSAID-containing products. NSAIDs may be present in over-the-counter medications for treatment of colds, fever or insomnia; refer to the label of over-the-counter medications you are taking or ask your pharmacist.

Using DUEXIS with other medicines can cause serious side effects. DUEXIS may affect the way other medicines work, and other medicines may affect how DUEXIS works. Especially tell your doctor if you take:

  • Aspirin
  • Warfarin (Coumadin®)

Where can I get more information about DUEXIS?

Ask your health care provider about DUEXIS; only your health care provider can offer information that is specific to your own health history.

What is an NSAID?

Nonsteroidal anti-inflammatory drugs are used to treat pain and redness, swelling and heat (inflammation) from medical conditions, including different types of arthritis (eg, osteoarthritis and rheumatoid arthritis).

What is famotidine?

Famotidine is an H2-receptor antagonist, a medicine that may help reduce stomach acid.

How should I take DUEXIS?

  • Take DUEXIS exactly as your health care provider tells you to take it
  • Your health care provider will tell you how many DUEXIS tablets to take and when to take them
  • Do not change your dose or stop taking DUEXIS without first talking to your health care provider
  • Swallow DUEXIS tablets whole. Do not split, chew, crush, or dissolve the tablets

What do I do if I think I have taken too much DUEXIS?

If you take too much DUEXIS, tell your health care provider or go to the nearest emergency room right away.

What if I forget to take a dose of DUEXIS?

If you forget to take a dose of DUEXIS, take it as soon as you remember. If it is almost time for your next dose, do not take the missed dose. Take the next dose on time. Do not take 2 doses at 1 time to make up for a missed dose.

How should I store my DUEXIS?

  • Store DUEXIS at 59°F to 86°F (15°C to 30°C)
  • Keep DUEXIS in the original container and keep the bottle tightly closed
  • Keep DUEXIS dry